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KMID : 0928520110210010011
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Korean Journal of Lipidology
2011 Volume.21 No. 1 p.11 ~ p.20
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Association between Bone Mineral Density and Cardiovascular Disease Risk Factor in Postmenopausal Women with Type 2 Diabetes
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Choi Yeon-Kyung
Ha In-Kyun
Kim Jong-Ho
Seo Hyun-Ae
Jeong Ji-Yun
Jeon Eon-Ju
Lee Jung-Eun
Lee In-Kyu
Kim Jung-Guk
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Abstract
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Objective: Recent studies suggest a possible pathogenic linkage between the osteoporosis and atherosclerosis. We investigated the relationship between cardiovascular risk factors and bone mineral density of lumbar spine (L1 to L4) and Femur neck in postmenopausal women with type 2 diabetes.
Methods: Anthropometric measurement were performed on 171 women and cardiovascular risk factors, including body mass index (BMI), lipid profile, coronary calcium scores via multi-detector row computed tomography (MDCT). Bone mineral density (BMD) of lumbar spine and femur neck were measured using dual X-ray absorptiometry.
Results: From bivariate analyses, lumbar spine (p=0.011) and femur neck BMD (p=0.000) showed negative correlations with coronary calcium scores. From multiple linear regression analyses of all the study subjects, age, BMI and apolipoprotein B were found to be determinants of the lumbar spine BMD (R2=0.156, p=0.049). The presence of severe amounts of coronary calcium on CT (score >75 percentile) was found to be determinants of the lumbar spine BMD (R2=0.367, p=0.035).
Conclusion: The results of our study suggest that lumbar spine BMD was negatively correlated with the apolipoprotein B and coronary artery calcification in postpermenopausal women with type 2 diabetes.
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KEYWORD
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Bone density, Apolipoprotein B, Cardiovascular disease, Type 2 diabetes mellitus
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